Key result
Lipoprotein lipase regulation by apolipoproteins and angiopoietin-like proteins plays a crucial role in lipid homeostasis and may offer new pharmacological targets for atherosclerosis.
Why the study?
Hypertriglyceridemia is an independent and residual risk factor for cardiovascular disease, making understanding LPL regulation crucial for identifying new pharmacological targets in atherosclerosis.
Design
Review
Authors
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Does not yet warrant new therapies for atherosclerosis; leaves open LPL regulators as targets for future trials in hypertriglyceridemia.
Understanding the regulation of lipoprotein lipase by apolipoproteins and ANGPTLs may provide new pharmacological targets for managing hypertriglyceridemia and residual ASCVD risk.
Kumari et al. (2021) conducted a review in Atherosclerosis and Hypertriglyceridemia. Lipoprotein lipase (LPL) regulation was evaluated. Lipoprotein lipase regulation by apolipoproteins and angiopoietin-like proteins plays a crucial role in lipid homeostasis and may offer new pharmacological targets for atherosclerosis.
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