Biventricular pacing and cardiac resynchronization therapy (CRT) led to profound regression of the dilated-hypokinetic state in a patient with end-stage hypertrophic cardiomyopathy.
Case Report (n=1)
Does biventricular pacing and cardiac resynchronization therapy (CRT) improve the dilated-hypokinetic state in patients with end-stage hypertrophic cardiomyopathy?
Biventricular pacing and CRT may reverse the 'burnt-out' dilated-hypokinetic end-stage manifestation of hypertrophic cardiomyopathy, warranting further systematic studies.
The evolution of hypertrophic cardiomyopathy (HCM) towards dilatation and hypokinesis is an increasingly recognized complication with a high incidence of adverse outcomes, including sudden cardiac death, requiring defibrillator implantation and cardiac transplantation. It is generally regarded as the irreversible 'burnt-out' end-stage manifestation of HCM. We report one of the first cases of profound regression of the dilated-hypokinetic state by the application of biventricular pacing and cardiac resynchronization therapy (CRT). Reviewing the literature on the role of pacing in HCM and the energetic rationale for CRT in HCM prompts us to suggest that further systematic studies are needed urgently to assess the role of CRT in HCM variants.
Ashrafian et al. (Mon,) conducted a case report in Dilated-hypokinetic hypertrophic cardiomyopathy (n=1). Biventricular pacing and cardiac resynchronization therapy (CRT) was evaluated on Regression of the dilated-hypokinetic state. Biventricular pacing and cardiac resynchronization therapy (CRT) led to profound regression of the dilated-hypokinetic state in a patient with end-stage hypertrophic cardiomyopathy.
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