Increased mean platelet volume on admission was independently associated with a decreased incidence of pre-PCI patent infarct-related artery (P=0.004) and post-PCI normal TIMI flow (P<0.001).
Observational (n=840)
p-value: p=<0.001
Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 840 patients with STEMI who underwent primary percutaneous coronary intervention (PCI). The patients were divided into 3 groups according to MPV tertiles. Pre- and post-PCI Thrombolysis In Myocardial Infarction (TIMI) flow grade was determined. Initial TIMI flow grade 3 was accepted as patent IRA. After the primary PCI, normal flow was defined as post-PCI TIMI flow 3. When the MPV was increased, the incidence of pre-PCI patent IRA (P = .004) and post-PCI normal TIMI flow (P < .001) was significantly decreased. Multivariate analysis showed that MPV was independently associated with post-PCI TIMI flow grade.
Elbasan et al. (Thu,) conducted a observational in ST-Segment Elevation Myocardial Infarction (STEMI) (n=840). Mean platelet volume (MPV) vs. Lower MPV tertiles was evaluated on Pre-PCI patent infarct-related artery and post-PCI normal TIMI flow (p=<0.001). Increased mean platelet volume on admission was independently associated with a decreased incidence of pre-PCI patent infarct-related artery (P=0.004) and post-PCI normal TIMI flow (P<0.001).