The combined use of oral contraceptives and smoking was associated with a 7.2-fold increased risk of acute myocardial infarction compared with non-smokers and non-users (RR 7.2; 95% CI 2.1-24.7).
Cohort (n=2,653)
Yes
Does the use of oral contraceptives and smoking increase the risk of acute myocardial infarction in women aged 35-49 years?
The combined use of oral contraceptives and smoking synergistically increases the risk of acute myocardial infarction in young women.
Relative Risk: 7.2 (95% CI 2.1–24.7)
The use of oral contraceptives (OC) and smoking habits were studied by using a questionnaire in a random population sample of women from two counties of Eastern Finland in 1972. The participation rate was 95%. Data on use of OC and smoking were collected for 2,653 women aged 35-49 years. During the next seven years, 27 of them had developed an acute myocardial infarction (AMI). Smokers had a 2.6-fold (95% confidence interval (CI)=1.2-6.0) crude risk of developing AMI compared with non-smokers. Women taking OC had a 1.3-fold (95% CI = 0.4-6.9) risk of developing AMI compared with those who did not. Women who both smoked and used OC had a 7.2-fold (95% CI = 2.1-24.7) risk of AMI compared with non-smokers and non-users of OC. The results indicate that use of OC is associated with an excessive risk of AMI among female smokers.
Jukka T. Salonen (Tue,) conducted a cohort in Acute myocardial infarction (n=2,653). Oral contraceptives and smoking vs. Non-smokers and non-users of oral contraceptives was evaluated on Acute myocardial infarction (AMI) (RR 7.2, 95% CI 2.1-24.7). The combined use of oral contraceptives and smoking was associated with a 7.2-fold increased risk of acute myocardial infarction compared with non-smokers and non-users (RR 7.2; 95% CI 2.1-24.7).
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