Orthostatic hypotension at baseline was associated with an increased risk of incident coronary heart disease after adjusting for demographics and cardiovascular risk factors (HR 1.85; 95% CI 1.31-2.63).
Cohort (n=12,433)
Yes
Hazard Ratio: 1.85 (95% CI 1.31–2.63)
We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a SBP decrease > or = 20 mm Hg or a DBP decrease > or = 10 mm Hg after changing from supine to standing. CHD events included definite or probable myocardial infarctions (MI), silent MI, and fatal CHD. Five percent of participants had OH. Prevalence increased with advancing age and was more common among those with cardiovascular disease (CVD)-related comorbidities and risk factors. Those with OH had an increased risk of CHD (hazard ratio HR = 3.49, 95% confidence interval CI = 2.58, 4.73). This association was attenuated after controlling for age, ethnicity, gender, comorbid conditions, and CVD risk factors (HR = 1.85, 95% CI = 1.31, 2.63).
Rose et al. (Thu,) conducted a cohort in Coronary heart disease (n=12,433). Orthostatic hypotension vs. No orthostatic hypotension was evaluated on Incidence of coronary heart disease (CHD) (HR 1.85, 95% CI 1.31-2.63). Orthostatic hypotension at baseline was associated with an increased risk of incident coronary heart disease after adjusting for demographics and cardiovascular risk factors (HR 1.85; 95% CI 1.31-2.63).