Key result
Orthostatic hypotension at baseline was associated with an increased risk of incident coronary heart disease after adjusting for demographics and cardiovascular risk factors (HR 1.85; 95% CI 1.31-2.63).
Why the study?
Does orthostatic hypotension increase the incidence of coronary heart disease in middle-aged adults?
Population
12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities…
Comparison
Presence of orthostatic hypotension at baseline vs Absence of orthostatic hypotension at baseline
Design
Cohort
Follow-up
average of 6 years
Authors
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May inform CHD risk stratification in middle-aged adults; leaves open causality and intervention effects.
Cohort (n=12,433)
Yes
Does orthostatic hypotension increase the incidence of coronary heart disease in middle-aged adults?
Hazard Ratio: 1.85 (95% CI 1.31–2.63)
Orthostatic hypotension is an independent risk factor for the development of incident coronary heart disease in middle-aged adults.
Rose et al. (2000) conducted a cohort in Coronary heart disease (n=12,433). Orthostatic hypotension vs. No orthostatic hypotension was evaluated on Incidence of coronary heart disease (CHD) (HR 1.85, 95% CI 1.31-2.63). Orthostatic hypotension at baseline was associated with an increased risk of incident coronary heart disease after adjusting for demographics and cardiovascular risk factors (HR 1.85; 95% CI 1.31-2.63).
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