Key result
Orthostatic hypotension did not independently predict coronary events (adjusted RR 1.25; 95% CI 0.82-1.88) or other cardiovascular outcomes after adjusting for age, gender, and systolic blood pressure.
Why the study?
Does orthostatic hypotension increase the risk of cardiovascular events in elderly individuals?
Population
1,016 men and women aged ≥65 years
Comparison
Orthostatic hypotension vs Subjects without orthostatic hypotension
Design
Cohort
Follow-up
12 years
Authors
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OH may not raise CV event risk in community elderly; leaves open need for targeted trials.
Cohort (n=1,016)
Does orthostatic hypotension increase the risk of cardiovascular events in elderly individuals?
Relative Risk: 1.25 (95% CI 0.82–1.88)
Absolute Event Rate: 20.2% vs 13.1%
p-value: p=0.05
Orthostatic hypotension does not independently predict cardiovascular events in the elderly when adjusting for biological confounders like age and systolic blood pressure.
Casiglia et al. (2013) conducted a cohort in Orthostatic hypotension (n=1,016). Orthostatic hypotension vs. Subjects without orthostatic hypotension was evaluated on Coronary events (RR 1.25, 95% CI 0.82-1.88, p=0.05). Orthostatic hypotension did not independently predict coronary events (adjusted RR 1.25; 95% CI 0.82-1.88) or other cardiovascular outcomes after adjusting for age, gender, and systolic blood pressure.
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