Mice (model of stress-induced cardiomyopathy via beta-adrenergic stimulation)
Beta-adrenergic stimulation
Identification of genes and pathways underlying specific pathological features of cardiomyopathies (stress-induced cardiac fibrosis)
Systems genetics identified Abcc6 as a novel genetic contributor to stress-induced cardiac fibrosis in mice.
Genetic variants significantly contribute to the phenotypic heterogeneity of stress-induced cardiomyopathy. Systems genetics is an effective approach to identify genes and pathways underlying the specific pathological features of cardiomyopathies. Abcc6 is a previously unrecognized player in the development of stress-induced cardiac fibrosis.
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Christoph Rau
Northwestern University
Jessica Wang
General Cardiology
Rozeta Avetisyan
Circulation Cardiovascular Genetics
University of California, Los Angeles
University of California System
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Rau et al. (Sat,) studied this question.
synapsesocial.com/papers/69d91a91ccb0bba5a5684132 — DOI: https://doi.org/10.1161/circgenetics.113.000732