Systems genetics identified Abcc6 as a novel genetic contributor to stress-induced cardiac fibrosis in mice.
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Identifies a novel therapeutic target for stress-induced cardiac fibrosis; leaves open whether.
Genetic variants significantly contribute to the phenotypic heterogeneity of stress-induced cardiomyopathy. Systems genetics is an effective approach to identify genes and pathways underlying the specific pathological features of cardiomyopathies. Abcc6 is a previously unrecognized player in the development of stress-induced cardiac fibrosis.
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Rau et al. (2014) studied this question.
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