Left atrial volume normalized for body surface area was strongly associated with mortality (HR 1.027; 95% CI 1.018-1.04; p<0.001), independent of exercise tolerance and ejection fraction.
Cohort (n=273)
Does left atrial volume provide independent prognostic information compared with exercise tolerance parameters in patients with chronic heart failure?
Left atrial volume normalized for body surface area provides powerful prognostic information independent of exercise tolerance and ejection fraction in patients with chronic heart failure.
Hazard Ratio: 1.027 (95% CI 1.018–1.04)
p-value: p=<0.001
OBJECTIVE: Left atrial volume (LAV) is a powerful predictor of outcome in patients with chronic heart failure (CHF) independently of symptomatic status, age and left ventricular (LV) function. It is unknown whether LAV provides independent and incremental information compared with exercise tolerance parameters. METHODS: 273 patients with CHF (mean (SD) 62 (9) years; 13% female) prospectively underwent echocardiography and exercise testing with maximal oxygen consumption (Vo(2)). The primary end point was composite and included cardiac death, hospitalisation for worsening heart failure or cardiac transplantation. RESULTS: At Cox proportional hazard analysis, LAV normalised for body surface area (LAV/BSA) was strongly associated with mortality (hazard ratio (HR) = 1.027 (95% CI 1.018 to 1.04), p63 ml, EF <30% and Vo(2) <16 ml/kg/min were considered to be risk factors. Patients with three risk factors had an HR of 38 (95% CI 11 to 129) compared with patients with no risk factors. CONCLUSION: LAV provides powerful prognostic information incrementally and independently of Vo(2). LAV, EF and Vo(2 )can be used to build a risk prediction model, which can be used clinically.
Rossi et al. (Tue,) conducted a cohort in chronic heart failure (CHF) (n=273). Left atrial volume normalized for body surface area (LAV/BSA) was evaluated on Composite of cardiac death, hospitalisation for worsening heart failure or cardiac transplantation (HR 1.027, 95% CI 1.018-1.04, p=<0.001). Left atrial volume normalized for body surface area was strongly associated with mortality (HR 1.027; 95% CI 1.018-1.04; p<0.001), independent of exercise tolerance and ejection fraction.