What is the clinical evidence from this study?

Study design: Cohort. Population: chronic heart failure (CHF) (n=273). Intervention: Left atrial volume normalized for body surface area (LAV/BSA). Primary outcome: Composite of cardiac death, hospitalisation for worsening heart failure or cardiac transplantation (HR 1.027, 95% CI 1.018-1.04, p=<0.001).

What question did this study set out to answer?

To determine if left atrial volume (LAV) provides independent and incremental prognostic information compared to exercise tolerance parameters in chronic heart failure patients.

December 12, 2006HeartOpen Access

Left atrial volume provides independent and incremental information compared with exercise tolerance parameters in patients with heart failure and left ventricular systolic dysfunction

Q: What are the key findings of this study?

Left atrial volume normalized for body surface area was strongly associated with mortality (HR 1.027; 95% CI 1.018-1.04; p<0.001), independent of exercise tolerance and ejection fraction.

Q: What question did this study set out to answer?

To determine if left atrial volume (LAV) provides independent and incremental prognostic information compared to exercise tolerance parameters in chronic heart failure patients.

View Full Paper

Ask AI

Bookmark

Key result

Left atrial volume normalized for body surface area was strongly associated with mortality (HR 1.027; 95% CI 1.018-1.04; p<0.001), independent of exercise tolerance and ejection fraction.

Why the study?

Does left atrial volume provide independent prognostic information compared with exercise tolerance parameters in patients with chronic heart failure?

Population

273 patients with chronic heart failure and left ventricular systolic dysfunction, mean age 62 years, 13%…

Comparison

Measurement of left atrial volume normalized for… vs Exercise tolerance parameters and left…

Design

Cohort

Authors

ARAndrea RossiUniversity of Siena MCMaria Antonietta CicoiraUniversity of Verona SBStefano BonapaceUniversity of Verona

Discussion

Member takes

Implication

LAV may refine CHF risk stratification beyond Vo2; leaves open whether it alters management or warrants prospective validation.

Key Points

To determine if left atrial volume (LAV) provides independent and incremental prognostic information compared to exercise tolerance parameters in chronic heart failure patients.
273 patients with chronic heart failure underwent echocardiography and exercise testing.
Primary endpoint was composite cardiac death, hospitalization for worsening heart failure, or cardiac transplantation.
Cox proportional hazard analysis assessed relationships between LAV, exercise tolerance, and outcomes.
LAV/BSA was strongly associated with mortality (HR=1.027, 95% CI 1.018-1.04, p<0.001).
LAV/BSA predictive value was independent of Vo(2) and left ventricular ejection fraction (EF).
Patients with three risk factors (LAV/BSA >63 ml, EF <30%, Vo(2) <16 ml/kg/min) had an HR of 38 (95% CI 11-129) compared to those without.

Study Design

Type

Cohort (n=273)

Structured PICO

Does left atrial volume provide independent prognostic information compared with exercise tolerance parameters in patients with chronic heart failure?

Population

273 patients with chronic heart failure (mean age 62 years, 13% female) who prospectively underwent echocardiography and exercise testing.

Exposure

Measurement of left atrial volume normalized for body surface area (LAV/BSA) via echocardiography

Comparator

Exercise tolerance parameters (maximal oxygen consumption [Vo2]) and left ventricular ejection fraction (EF)

Outcome

Composite of cardiac death, hospitalisation for worsening heart failure or cardiac transplantationcomposite

Main Result

Hazard Ratio: 1.027 (95% CI 1.018–1.04)

p-value: p=<0.001

Left atrial volume normalized for body surface area provides powerful prognostic information independent of exercise tolerance and ejection fraction in patients with chronic heart failure.

Cite This Study

Rossi et al. (2006) conducted a cohort in chronic heart failure (CHF) (n=273). Left atrial volume normalized for body surface area (LAV/BSA) was evaluated on Composite of cardiac death, hospitalisation for worsening heart failure or cardiac transplantation (HR 1.027, 95% CI 1.018-1.04, p=<0.001). Left atrial volume normalized for body surface area was strongly associated with mortality (HR 1.027; 95% CI 1.018-1.04; p<0.001), independent of exercise tolerance and ejection fraction.

synapsesocial.com/papers/6a63dcd166308486acb3625b https://doi.org/10.1136/hrt.2006.101261

Topics

HFrEF treatment Heart failure

View Full Paper

Ask AI

Bookmark

Left atrial volume provides independent and incremental information compared with exercise tolerance parameters in patients with heart failure and left ventricular systolic dysfunction

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Left atrial volume provides independent and incremental information compared with exercise tolerance parameters in patients with heart failure and left ventricular systolic dysfunction

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider