Patients with Heart Failure with Preserved Ejection Fraction (HFPEF)
Cardiomyocyte F(passive) and myocardial nitrosative/oxidative stresssurrogate
Low myocardial PKG activity contributes to increased cardiomyocyte stiffness and oxidative stress in HFPEF, suggesting it as a potential therapeutic target.
Low myocardial PKG activity in HFPEF was associated with raised cardiomyocyte F(passive) and was related to increased myocardial nitrosative/oxidative stress. The latter was probably induced by the high prevalence in HFPEF of metabolic comorbidities. Correction of myocardial PKG activity could be a target for specific HFPEF treatment.
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Loek van Heerebeek
Nazha Hamdani
Inês Falcão‐Pires
Circulation
Universidade do Porto
Elisabeth-TweeSteden Ziekenhuis
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Heerebeek et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69df2bd382ee7f203061409a — DOI: https://doi.org/10.1161/circulationaha.111.076075
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