Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
Population
Patients with Heart Failure with Preserved Ejection Fraction (HFPEF)
Design
Other
Authors
Discussion
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Member takes
Implication
Should not yet alter HFpEF care; supports PKG pathway as hypothesis-generating target for future trials.
Structured PICO
P
Population
Patients with Heart Failure with Preserved Ejection Fraction (HFPEF)
O
Outcome
Cardiomyocyte F(passive) and myocardial nitrosative/oxidative stresssurrogate
Low myocardial PKG activity contributes to increased cardiomyocyte stiffness and oxidative stress in HFPEF, suggesting it as a potential therapeutic target.
Cite This Study
Heerebeek et al. (2012) studied this question.