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Dapagliflozin-induced SGLT2 inhibition for 12 weeks is associated with reductions in 24-h BP, body weight, GFR and possibly plasma volume. Cumulatively, these effects suggest that dapagliflozin may have a diuretic-like capacity to lower BP in addition to beneficial effects on glycaemic control.
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Diabetes Obesity and Metabolism
University of Groningen
University Medical Center Groningen
Zimmer Biomet (United States)
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Heerspink et al. (Mon,) studied this question.