A computational survey of Picornaviridae genomes identified smaller conserved sections of the IRES region than previously reported, significant structural elements in the coding region, and potential cis-acting replication elements.
Provides a comprehensive computational survey identifying conserved RNA secondary structures and potential cis-acting replication elements in Picornaviridae genomes.
The family Picornaviridae contains important pathogens including, for example, hepatitis A virus and foot-and-mouth disease virus. The genome of these viruses is a single messenger-active (+)-RNA of 7200-8500 nt. Besides coding for the viral proteins, it also contains functionally important RNA secondary structures, among them an internal ribosomal entry site (IRES) region towards the 5'-end. This contribution provides a comprehensive computational survey of the complete genomic RNAs and a detailed comparative analysis of the conserved structural elements in seven of the currently nine genera in the family PICORNAVIRIDAE: Compared with previous studies we find: (i) that only smaller sections of the IRES region than previously reported are conserved at single base-pair resolution and (ii) that there is a number of significant structural elements in the coding region. Furthermore, we identify potential cis-acting replication elements in four genera where this feature has not been reported so far.
Christina Witwer (2001) studied Picornaviridae genomes. Computational survey and comparative analysis was evaluated on Conserved RNA secondary structures. A computational survey of Picornaviridae genomes identified smaller conserved sections of the IRES region than previously reported, significant structural elements in the coding region, and potential cis-acting replication elements.
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