Key result
A computational survey of Picornaviridae genomes identified smaller conserved sections of the IRES region than previously reported, significant structural elements in the coding region, and potential cis-acting replication elements.
Population
Complete genomic RNAs of seven genera in the family Picornaviridae
Design
Preclinical
Authors
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Computational mapping of picornaviral RNA structures requires experimental validation; leaves open whether identified elements represent viable antiviral targets.
Provides a comprehensive computational survey identifying conserved RNA secondary structures and potential cis-acting replication elements in Picornaviridae genomes.
Christina Witwer (2001) studied Picornaviridae genomes. Computational survey and comparative analysis was evaluated on Conserved RNA secondary structures. A computational survey of Picornaviridae genomes identified smaller conserved sections of the IRES region than previously reported, significant structural elements in the coding region, and potential cis-acting replication elements.
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