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January 1, 1989Nucleic Acids ResearchOpen Access

Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs

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Population

Published nucleotide sequences of the 5'-untranslated region of 7 cardioviruses and 3 aphthoviruses, and…

Design

Preclinical

Authors

EPEvgeny V. PilipenkoUniversity of ChicagoVBVladimir M. BlinovResearch Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical SciencesBCB. K. ChernovAkonni Biosystems (United States)

Discussion

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Implication

Offers no immediate clinical implications for viral myocarditis; leaves open functional roles in translational control pending validation.

Structured PICO

P
Population
Published nucleotide sequences of the 5'-untranslated region (5'-UTR) of 7 cardioviruses and 3 aphthoviruses, and encephalomyocarditis virus RNA
I
Intervention
Modifications with dimethyl sulfate and susceptibility to S1 and cobra venom nucleases
O
Outcome
Consensus secondary structure model of the 5'-UTR

The study provides a consensus secondary structure model for the 5'-UTR of cardio- and aphthoviruses, highlighting differences from other Picornaviridae and suggesting involvement in translational control.

Cite This Study

Pilipenko et al. (1989) studied this question.

synapsesocial.com/papers/6a225cce7d05348b2ab600d4https://doi.org/10.1093/nar/17.14.5701
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus1987 · 100 citations
  2. 2A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation1988 · 1,378 citations
  3. 3An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis1988 · 173 citations
  4. 4Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses1987 · 180 citations
  5. 5Effects of cDNA hybridization on translation of encephalomyocarditis virus RNA1987 · 49 citations