Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1993Nucleic Acids ResearchOpen Access

Conserved tertiary structural elements in the 5’ nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs

View Full Paper
Ask AI
Bookmark
Share

Population

5' nontranslated regions of encephalomyocarditis virus, Theiler's murine encephalomyelitis virus…

Design

Preclinical

Authors

SLShu‐Yun LeNanchang UniversityJCJih-H. ChenScience Applications International Corporation (United States)
Nahum Sonenberg
Nahum SonenbergRutgers, The State University of New Jersey

Discussion

Loading...

Member takes

Implication

May guide RNA-targeted antiviral design; leaves open validation in human viral disease.

Structured PICO

P
Population
5' nontranslated regions (5'NTR) of encephalomyocarditis virus, Theiler's murine encephalomyelitis virus, foot-and-mouth disease virus, and hepatitis A virus RNAs
I
Intervention
Statistical analyses of RNA folding and Monte Carlo simulations
O
Outcome
Conserved tertiary structural elements and folding regions

The study identifies conserved tertiary structural elements in the 5'NTR of several viral RNAs that may be critical for internal ribosome binding and cap-independent translation.

Cite This Study

Le et al. (1993) studied this question.

synapsesocial.com/papers/6a8212646cfba4e31a9fd86ahttps://doi.org/10.1093/nar/21.10.2445
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs1989 · 203 citations
  2. 2The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro1991 · 211 citations
  3. 3Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus1992 · 34 citations
  4. 4A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses1990 · 87 citations
  5. 5A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation1988 · 1,377 citations