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November 1, 1991Journal of VirologyOpen Access

The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro

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Population

Hepatitis A virus (HAV) strains (PA21 and CF53) and RNA transcripts translated in rabbit reticulocyte lysates

Comparison

Progressive 5' deletions of the HAV 5'… vs Undeleted 5'NTR / genomic-length HAV RNA

Design

Preclinical

Authors

EBEdwin A. BrownUniversity of North Carolina at Chapel HillSDStephen DayGeorgetown UniversityRJRobert W. JansenUniversity of North Carolina at Chapel Hill

Discussion

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Implication

May inform HAV translation models; leaves open clinical relevance pending human validation.

Structured PICO

P
Population
Hepatitis A virus (HAV) strains (PA21 and CF53) and RNA transcripts translated in rabbit reticulocyte lysates
I
Intervention
Progressive 5' deletions of the HAV 5' nontranslated region (5'NTR)
C
Comparator
Undeleted 5'NTR / genomic-length HAV RNA
O
Outcome
Translation efficiency (production of truncated, unprocessed P1 polyprotein)

Sequences 3' of base 355 in the HAV 5'NTR play an important role in translation, sharing structural features with the internal ribosome entry site of murine encephalomyocarditis virus.

Cite This Study

Brown et al. (1991) studied this question.

synapsesocial.com/papers/6a7cfe0c3d640844b95e05bahttps://doi.org/10.1128/jvi.65.11.5828-5838.1991
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular cloning and partial sequencing of hepatitis A viral cDNA1985 · 75 citations
  2. 2An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells1991 · 102 citations
  3. 3Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs1989 · 203 citations
  4. 4Attenuation and cell culture adaptation of hepatitis A virus (HAV): a genetic analysis with HAV cDNA1989 · 70 citations
  5. 5An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis1988 · 173 citations