Increased daytime systolic blood pressure variability was associated with significantly greater progression of carotid intima-media thickness (0.11 vs 0.05 mm/y; P<0.005).
Cohort (n=286)
Does increased daytime systolic blood pressure variability predict the progression of early carotid atherosclerosis in patients aged >55 years?
Increased daytime systolic blood pressure variability is a strong predictor of early carotid atherosclerosis progression and cardiovascular events.
Absolute Event Rate: 0.11% vs 0.05%
p-value: p=<0.005
BACKGROUND: Arterial hypertension is a major risk factor for cardiovascular damage. The results of several studies suggest that target organ damage is greater in hypertensive persons with high blood pressure variability. METHODS AND RESULTS: During 3.3 years of follow-up, we studied the relationship between circadian blood pressure changes and the progression of early carotid atherosclerosis in 286 patients aged >55 years. Blood pressure patterns were evaluated with a long-term blood pressure monitor, and the extent of atherosclerosis was measured as the intima-media wall thickness (IMT) of the common carotid artery. Patients were subdivided according to blood pressure variability. The progression of IMT was significantly greater in the patients with increased systolic blood pressure variability (0.11 mm/y 95% CI 0.09 to 0.14 versus 0.05 mm/y 0.03 to 0.08; P:15 mm Hg) is associated with an increased relative risk of the development of early atherosclerosis (3.9 1.4 to 11.1; P:<0.01) and of cardiovascular events (1.87 1.08 to 3.20; P:<0.01). CONCLUSIONS: The daytime systolic blood pressure variability is a strong predictor of early carotid atherosclerosis progression and is useful to define the risk-benefit ratio of therapeutic approaches.
Sander et al. (Tue,) conducted a cohort in Early carotid atherosclerosis (n=286). Increased systolic blood pressure variability vs. Lower systolic blood pressure variability was evaluated on Progression of intima-media wall thickness (IMT) (p=<0.005). Increased daytime systolic blood pressure variability was associated with significantly greater progression of carotid intima-media thickness (0.11 vs 0.05 mm/y; P<0.005).