November 9, 2004Open Access
View Full PaperMobilization of CD34/CXCR4 + , CD34/CD117 + , c-met + Stem Cells, and Mononuclear Cells Expressing Early Cardiac, Muscle, and Endothelial Markers Into Peripheral Blood in Patients With Acute Myocardial Infarction
Structured PICO
P
Population
Patients with Acute Myocardial Infarction (STEMI)
O
Outcome
Mobilization of mononuclear cells expressing specific cardiac, muscle, and endothelial markers as well as CD34/CXCR4+ and CD34/CD117+ and c-met+ stem cells into peripheral bloodsurrogate
STEMI triggers the mobilization of specific stem and progenitor cells into peripheral blood, a process in which stromal cell-derived factor-1 plays an important role.
Abstract
The study demonstrates in the setting of STEMI a marked mobilization of mononuclear cells expressing specific cardiac, muscle, and endothelial markers as well as CD34/CXCR4+ and CD34/CD117+ and c-met+ stem cells and shows that stromal cell-derived factor-1 is an important factor influencing the mobilization.