What is the clinical evidence from this study?

Study design: Observational. Population: Acute gastroenteritis (n=373). Primary outcome: Prevalence of Saffold cardiovirus (SAFV).

September 1, 2009Open Access

Saffold Cardiovirus in Children with Acute Gastroenteritis, Beijing, China

Key Result

Saffold cardiovirus was detected in 3.2% (12 of 373) of children with acute gastroenteritis in Beijing, China, with most cases involving co-infection with other enteric viruses.

Study Design

Type

Observational (n=373)

Multicenter

Structured PICO

Population

373 pediatric outpatients with acute gastroenteritis (acute watery diarrhea accompanied by other clinical signs and symptoms such as fever, nausea, and vomiting, with no apparent clinical respiratory signs or symptoms), ages 1 month to 13 years (mean age 11.7 months, median age 9.0 months), at Beijing Children's Hospital.

Outcome

Prevalence and sequence homology of Saffold cardiovirus (SAFV)

Saffold cardiovirus (SAFV-1 sublineage) is present in a small percentage of children with acute gastroenteritis in China, though its clinical role remains unclear due to frequent co-infections.

Limitations

High rate of co-infection with other known diarrhea-causing viruses prevents conclusively stating that SAFV is responsible for gastroenteritis.
Insufficient background information from outpatients to determine if the detection peak in a single month indicates a true seasonal outbreak.

Abstract

To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied SAFV in children with acute gastroenteritis and found SAFV in 12 (3.2%) of 373. Sequence homology of virus protein 1 genes suggested these strains belong to the SAFV-1 sublineage. SAFVs were found in samples positive for other diarrhea-causing viruses.

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