September 16, 2015Open Access
View Full PaperLeft Ventricular Structure and Risk of Cardiovascular Events: A Framingham Heart Study Cardiac Magnetic Resonance Study
Structured PICO
Does greater LVMI and LV concentric hypertrophy increase the risk of adverse incident CVD events in adults free of prevalent CVD?
P
Population
Adults free of prevalent cardiovascular disease in the community (Framingham Heart Study cohort)
I
Intervention
Greater left ventricular mass index (LVMI) and LV concentric hypertrophy assessed by Cardiac Magnetic Resonance (CMR)
C
Comparator
Normal left ventricular mass and geometry
O
Outcome
Adverse incident cardiovascular disease (CVD) eventshard clinical
Increased left ventricular mass index and concentric hypertrophy identified by CMR in asymptomatic adults strongly predict future cardiovascular events, suggesting a potential target for primary prevention.
Abstract
Among adults free of prevalent CVD in the community, greater LVMI and LV concentric hypertrophy are associated with a marked increase in adverse incident CVD events. The potential benefit of aggressive primary prevention to modify LV mass and geometry in these adults requires further investigation.