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A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R. PLA(2)R is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that PLA(2)R is a major antigen in this disease.
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Laurence H. Beck
Ramon Bonegio
Gérard Lambeau
New England Journal of Medicine
Boston University
University of Louisville
Institut de Pharmacologie Moléculaire et Cellulaire
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Beck et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d7d611f39344339dd18ac9 — DOI: https://doi.org/10.1056/nejmoa0810457