A self-reported history of depression was associated with a 3.27-fold increased odds of incident depression over 2.5 years in primary care patients with type 2 diabetes.
Cohort (n=2,460)
Yes
Depression is common and often chronic or recurrent in primary care patients with type 2 diabetes, with history of depression being a strong predictor.
Effect estimate: OR 3.27 (95% CI 2.05-5.22)
Absolute Event Rate: 33% vs 13%
p-value: p=<0.001
AIMS/HYPOTHESIS: The aim of the study was to examine the course (incidence, recurrence/persistence) of depressive symptoms in primary care patients with type 2 diabetes and to identify significant predictors of these different course patterns. METHODS: A cohort of 2,460 primary care patients with type 2 diabetes was assessed for demographic, clinical and psychological factors in 2005 and followed-up in 2007 and 2008. Depression was defined as a score of ≥ 12 on the Edinburgh Depression Scale. Multivariate logistic regression analyses were used to determine whether several depression-course patterns could be predicted by means of demographics, medical co-morbidities and psychological factors. RESULTS: A total of 630 patients (26%) met the criterion for depression at one or more assessments. In the subgroup with no baseline depression, incident depression at follow-up was present in 14% (n = 310), while recurrence/persistence in those with baseline depression was found in 66% (n = 212).The presence of any depression was associated with being female, low education, non-cardiovascular chronic diseases, stressful life events and a self-reported history of depression. Incident depression was predicted by female sex, low education and depression history, while patients with a history of depression had a 2.5-fold increased odds of recurrent/persistent depression. CONCLUSIONS/INTERPRETATION: Depression is common in primary care patients with type 2 diabetes, with one in seven patients reporting incident depression during a 2.5 year period. Once present, depression often becomes a chronic/recurrent condition in this group. In order to identify patients who are vulnerable to depression, clinicians can use questionnaire data and/or information about the history of depression.
Nefs et al. (Fri,) conducted a cohort in Type 2 diabetes (n=2,460). History of depression vs. No history of depression was evaluated on Incident depression (OR 3.27, 95% CI 2.05-5.22, p=<0.001). A self-reported history of depression was associated with a 3.27-fold increased odds of incident depression over 2.5 years in primary care patients with type 2 diabetes.