The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

Key Points

• This research aims to investigate the role of the NLRP3 inflammasome in cardiac fibroblasts following myocardial infarction.
• Assessed NLRP3 inflammasome levels in cardiac fibroblasts post-myocardial infarction (MI).
• Evaluated its contribution to infarct size during ischaemia-reperfusion injury.
• NLRP3 inflammasome was significantly up-regulated in cardiac fibroblasts after MI.
• Increased inflammasome activity correlated with larger infarct sizes during reperfusion.