Does the relation of blood pressure indices (DBP, SBP, PP) to coronary heart disease risk change with aging?
Patients evaluated for coronary heart disease (CHD) risk across different age groups (<50 years, 50 to 59 years, and ≥60 years)
Blood pressure indices (diastolic blood pressure [DBP], systolic blood pressure [SBP], and pulse pressure [PP])
Coronary heart disease (CHD) riskhard clinical
The predictive value of different blood pressure components for coronary heart disease risk changes significantly with age, shifting from diastolic blood pressure in younger patients to pulse pressure in older patients.
With increasing age, there was a gradual shift from DBP to SBP and then to PP as predictors of CHD risk. In patients <50 years of age, DBP was the strongest predictor. Age 50 to 59 years was a transition period when all 3 BP indexes were comparable predictors, and from 60 years of age on, DBP was negatively related to CHD risk so that PP became superior to SBP.
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Stanley S. Franklin
Preventive Cardiology
Martin G. Larson
Semmelweis University
Shehzad Akbar Khan
Khyber Medical College
Circulation
University of California, Irvine
National Heart Lung and Blood Institute
Framingham Heart Study
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Franklin et al. (Tue,) studied this question.
synapsesocial.com/papers/69d6b4c941375cf86eed8878 — DOI: https://doi.org/10.1161/01.cir.103.9.1245