Older women (ages 36-45) with PCOS had a four-fold increased odds of metabolic syndrome compared to younger women (OR 4.01; 95% CI 1.04-15.4; p=0.04).
Cross-Sectional (n=229)
Are there age-related differences in the reproductive and metabolic manifestations of PCOS in an obese US population?
Older women with PCOS have a significantly higher risk of metabolic syndrome and worse metabolic profiles compared to younger women with PCOS.
Effect estimate: OR 4.01 (95% CI 1.04-15.4)
p-value: p=0.04
The objective of this study was to explore age-related differences in the reproductive and metabolic manifestations of polycystic ovarian syndrome (PCOS). Using a prospective cross-sectional design, we compared metabolic and reproductive findings in women attending a multidisciplinary clinic for PCOS, stratified across the following age groups: 18-25 (n = 71), 26-35 (n = 129), and 36-45 (n = 29). The study included primarily overweight and obese women, with a mean BMI of 31.1 in the entire study group. Older women had a decreased prevalence of biochemical hyperandrogenemia (p-trend: 0.0005). Of women meeting diagnostic criteria for PCOS, older women (n = 15) had larger median waist circumference and higher median diastolic blood pressure, total cholesterol, LDL cholesterol and fasting glucose compared to younger women (p-trend: 0.03, 0.01, 0.01, 0.01 and 0.06, respectively). The odds of metabolic syndrome for women ages 36-45 are increased four-fold relative to the younger groups (OR: 4.01; 95% CI: 1.04-15.4; p = 0.04). We conclude that there are significant age-related differences in both the clinical presentation and metabolic manifestations of PCOS.
Johnstone et al. (Thu,) conducted a cross-sectional in Polycystic ovarian syndrome (PCOS) (n=229). Older age (36-45 years) vs. Younger age (18-35 years) was evaluated on Metabolic syndrome (OR 4.01, 95% CI 1.04-15.4, p=0.04). Older women (ages 36-45) with PCOS had a four-fold increased odds of metabolic syndrome compared to younger women (OR 4.01; 95% CI 1.04-15.4; p=0.04).