Key result
Older women (ages 36-45) with PCOS had a four-fold increased odds of metabolic syndrome compared to younger women (OR 4.01; 95% CI 1.04-15.4; p=0.04).
Why the study?
Are there age-related differences in the reproductive and metabolic manifestations of PCOS in an obese US population?
Cross-Sectional (n=229)
Are there age-related differences in the reproductive and metabolic manifestations of PCOS in an obese US population?
Effect estimate: OR 4.01 (95% CI 1.04-15.4)
p-value: p=0.04
Older women with PCOS have a significantly higher risk of metabolic syndrome and worse metabolic profiles compared to younger women with PCOS.
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May support age-stratified metabolic monitoring in PCOS; leaves open prospective validation and causal inference.
Johnstone et al. (2012) conducted a cross-sectional in Polycystic ovarian syndrome (PCOS) (n=229). Older age (36-45 years) vs. Younger age (18-35 years) was evaluated on Metabolic syndrome (OR 4.01, 95% CI 1.04-15.4, p=0.04). Older women (ages 36-45) with PCOS had a four-fold increased odds of metabolic syndrome compared to younger women (OR 4.01; 95% CI 1.04-15.4; p=0.04).
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