Native T1 and post-contrast T1 mapping reliably differentiated between healthy myocardium, acute inflammatory infiltrated myocardium, and chronic stages of experimental autoimmune myocarditis in rats.
Background Magnetic resonance imaging as a noninvasive method offers diagnostic and prognostic information in myocarditis. T1 mapping techniques aim to overcome the limitations of late gadolinium enhancement to assess diffuse fibrosis and inflammatory infiltrates. Using an established animal model of myocarditis, the aim of this study was to measure myocardial T1 before the onset, and in the acute and chronic stages of the disease and to compare its course with histological and immunohistochemistry findings.
Jeuthe et al. (Sun,) conducted a other in Experimental autoimmune myocarditis. Experimental autoimmune myocarditis vs. Healthy myocardium (baseline) was evaluated on Myocardial T1 (native and post-contrast) correlation with histology. Native T1 and post-contrast T1 mapping reliably differentiated between healthy myocardium, acute inflammatory infiltrated myocardium, and chronic stages of experimental autoimmune myocarditis in rats.