December 16, 2015Open Access

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3′-End Formation in the Failing Human Heart

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Abstract

We provide genome-wide, high-resolution polyadenylation maps of the human heart and show that the 3'end formation of mRNA is dynamic in heart failure, suggesting that APA-mediated 3'UTR length modulation represents an additional layer of gene regulation in failing hearts.

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Authors

Esther E. Creemers

Heart Failure & Transplant

Amira Bawazeer

Amsterdam UMC Location University of Amsterdam

Alejandro P. Ugalde

Universidad de Oviedo

Journals

Circulation Research

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Institutions

Imperial College London

The Netherlands Cancer Institute

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Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3′-End Formation in the Failing Human Heart

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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