Genome-wide transcriptomic analysis reveals dynamic mRNA 3'-end formation in failing human hearts, indicating alternative polyadenylation acts as an additional layer of cardiac gene regulation.
We provide genome-wide, high-resolution polyadenylation maps of the human heart and show that the 3'end formation of mRNA is dynamic in heart failure, suggesting that APA-mediated 3'UTR length modulation represents an additional layer of gene regulation in failing hearts.
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Creemers et al. (2015) studied this question.
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