Acute hypobaric exposure (simulated 3,000 m) blunted the plasma ANP response to maximal exercise compared to sea level (peak 22.3 vs 35.1 pmol/l; P<0.05).
Does maximal exercise in hypobaric conditions alter ANP secretion compared to sea level in young athletes?
Acute hypobaric exposure blunts the ANP response to maximal exercise compared to normobaric conditions, possibly due to increased elimination.
Absolute Event Rate: 22.3% vs 35.1%
p-value: p=<0.05
To evaluate the role of atrial natriuretic peptide (ANP) in exercise-related cardiovascular and hormonal adjustments in hypobaric conditions, 14 young athletes performed a maximal ergometer test in a hypobaric chamber adjusted to simulate the altitudes of sea level and 3,000 m. Plasma immunoreactive ANP levels rose from 5.89 to 35.1 pmol/l at sea level and rose significantly less (P less than 0.05), from 5.36 to 22.3 pmol/l, at simulated 3,000 m. Plasma immunoreactive amino-terminal peptide of proANP (NT-proANP) levels increased to the same extent at sea level and at simulated 3,000 m (from 240 to 481 pmol/l and from 257 to 539 pmol/l, respectively). Plasma immunoreactive aldosterone increased significantly less at simulated 3,000 m (P less than 0.05), but the changes in plasma renin were similar in both conditions. Plasma immunoreactive endothelin-1 and serum erythropoietin levels remained unchanged. In conclusion, we found a blunted ANP response to maximal exercise of ANP in acute hypobaric exposure compared with that in normobaric conditions, but no significant difference in the NT-proANP responses between the two conditions. The divergence may be due to stimulation of the elimination mechanism of ANP.
Vuolteenaho et al. (Tue,) conducted a other in Healthy (n=14). Acute hypobaric exposure (simulated 3,000 m) vs. Normobaric conditions (sea level) was evaluated on Plasma immunoreactive ANP levels post-exercise (p=<0.05). Acute hypobaric exposure (simulated 3,000 m) blunted the plasma ANP response to maximal exercise compared to sea level (peak 22.3 vs 35.1 pmol/l; P<0.05).