Broiler chickens, prone to pulmonary hypertension, exhibited significantly smaller endothelium-dependent relaxations to ACh and A23187 in pulmonary artery rings compared to Leghorns (P<0.05).
Broiler chickens, which are prone to pulmonary hypertension, exhibit reduced endothelium-derived nitric oxide activity and increased intrinsic tone in pulmonary arteries compared to resistant Leghorn chickens.
p-value: p=<0.05
Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent sodium nitroprusside (SNP), papaverine (PPV) vasodilators were compared in preconstricted pulmonary artery (PA) rings from these chicken strains. ACh (10(-7), 10(-6), and 10(-5) M)- and A23187 (10(-6) and 10(-5.5) M)-induced relaxations were smaller (P < 0.05) in broilers than Leghorns. N(G)-nitro-L-arginine methyl ester (10(-3.5) M) caused similar reductions in ACh-induced relaxations in both strains. L-Arginine (10(-4) M) enhanced ACh-induced relaxations more in broilers than Leghorns. Relaxations to 10(-10)-10(-6) M SNP did not differ between strains, but were greater (P < 0.05) in broilers than Leghorns at higher concentrations (10(-5) and 10(-4) M). PPV (10(-4) M)- and SNP (10(-4) M)-induced maximal relaxations were greater in broilers than in Leghorns (176.2 +/- 14.7 vs. 120.9 +/- 14.7% and 201.3 +/- 7.8 vs. 171.2 +/- 10.7%, respectively, P < 0.05). Broiler PA rings appear to have increased intrinsic tone and reduced endothelium-derived nitric oxide activity, both of which may contribute to the susceptibility of broiler chickens to pulmonary hypertension.
Martinez‐Lemus et al. (Thu,) conducted a other in Pulmonary hypertension. Broiler strain vs. Leghorn strain was evaluated on Endothelium-dependent (ACh, A23187) relaxations (p=<0.05). Broiler chickens, prone to pulmonary hypertension, exhibited significantly smaller endothelium-dependent relaxations to ACh and A23187 in pulmonary artery rings compared to Leghorns (P<0.05).