Key result
Broiler chickens, prone to pulmonary hypertension, exhibited significantly smaller endothelium-dependent relaxations to ACh and A23187 in pulmonary artery rings compared to Leghorns (P<0.05).
p-value: p=<0.05
Broiler chickens, which are prone to pulmonary hypertension, exhibit reduced endothelium-derived nitric oxide activity and increased intrinsic tone in pulmonary arteries compared to resistant Leghorn chickens.
May indicate endothelial NO impairment in avian PH models; leaves open translation to mammalian or human disease.
Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent [sodium nitroprusside (SNP), papaverine (PPV)] vasodilators were compared in preconstricted pulmonary artery (PA) rings from these chicken strains. ACh (10(-7), 10(-6), and 10(-5) M)- and A23187 (10(-6) and 10(-5.5) M)-induced relaxations were smaller (P < 0.05) in broilers than Leghorns. N(G)-nitro-L-arginine methyl ester (10(-3.5) M) caused similar reductions in ACh-induced relaxations in both strains. L-Arginine (10(-4) M) enhanced ACh-induced relaxations more in broilers than Leghorns. Relaxations to 10(-10)-10(-6) M SNP did not differ between strains, but were greater (P < 0.05) in broilers than Leghorns at higher concentrations (10(-5) and 10(-4) M). PPV (10(-4) M)- and SNP (10(-4) M)-induced maximal relaxations were greater in broilers than in Leghorns (176.2 +/- 14.7 vs. 120.9 +/- 14.7% and 201.3 +/- 7.8 vs. 171.2 +/- 10.7%, respectively, P < 0.05). Broiler PA rings appear to have increased intrinsic tone and reduced endothelium-derived nitric oxide activity, both of which may contribute to the susceptibility of broiler chickens to pulmonary hypertension.
No takes yet. Share an insight, caveat, or question.
Martinez‐Lemus et al. (1999) studied Pulmonary hypertension. Broiler strain vs. Leghorn strain was evaluated on Endothelium-dependent (ACh, A23187) relaxations (p=<0.05). Broiler chickens, prone to pulmonary hypertension, exhibited significantly smaller endothelium-dependent relaxations to ACh and A23187 in pulmonary artery rings compared to Leghorns (P<0.05).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: