What does this research mean for the field?

Glioblastoma-associated microglia and macrophages (GAMs) exist on a continuum between M1- and M2-like phenotypes and closely resemble nonpolarized M0 macrophages, challenging the current dogma regarding their immunological functions. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

February 24, 2016Open Access

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Key Points

Key points are not available for this paper at this time.

Abstract

cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Konrad Gabrusiewicz

Benjamin A.T. Rodriguez

Jun Wei

Journals

JCI Insight

Actions

Institutions

McGill University

The University of Texas MD Anderson Cancer Center

Baylor College of Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider