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February 24, 2016JCI Insight463 citationsOpen Access

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

KGKonrad GabrusiewiczBRBenjamin A.T. RodriguezJWJun Wei

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Abstract

cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.

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Gabrusiewicz et al. (2016) studied this question.

synapsesocial.com/papers/6a09815187ad1657d2516659https://doi.org/10.1172/jci.insight.85841
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