February 23, 2016Open Access
Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study
Structured PICO
Does assessment of coronary, aortic, and valvular calcification improve risk prediction for major coronary heart disease and CVD beyond standard risk factors in asymptomatic community-dwelling persons?
P
Population
Asymptomatic community-dwelling persons from the Framingham Heart Study
I
Intervention
Assessment of coronary, aortic, and valvular calcification (CAC)
C
Comparator
Standard cardiovascular risk factors
O
Outcome
Major coronary heart disease and cardiovascular disease (CVD) events (assessed via discrimination and risk reclassification)hard clinical
Coronary artery calcification scoring provides significant clinical value beyond traditional risk factors by accurately reclassifying the majority of intermediate-risk asymptomatic patients.
Abstract
CAC improves discrimination and risk reclassification for major coronary heart disease and CVD beyond risk factors in asymptomatic community-dwelling persons and accurately reclassifies two-thirds of the intermediate-risk population.
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Authors
U
Udo Hoffmann
Semmelweis University
Joseph M. Massaro
Preventive Cardiology
R
Ralph B. D’Agostino
Wake Forest University
Journals
Journal of the American Heart Association
SHILAP Revista de lepidopterología
Actions
Institutions
Harvard University
Brigham and Women's Hospital
Massachusetts General Hospital
References and Citations
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