A novel coupled left ventricle-systemic artery model accurately reproduced baseline physiological measurements and predicted varied pathological responses consistent with clinical observations.
A newly developed coupled left ventricle-systemic artery computational model accurately simulates cardio-arterial interactions in both healthy and pathological scenarios.
To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV-SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the systemic arteries (SA). The coupling of the LV model and the SA model is achieved by matching the pressure and the flow rate at the aortic root, i.e. the SA model feeds back the pressure as a boundary condition to the LV model, and the aortic flow rate from the LV model is used as the input for the SA model. The governing equations of the coupled system are solved using a combined immersed-boundary finite-element (IB/FE) method and a Lax-Wendroff scheme. A baseline case using physiological measurements of healthy subjects, and four exemplar cases based on different physiological and pathological scenarios are studied using the LV-SA model. The results of the baseline case agree well with published experimental data. The four exemplar cases predict varied pathological responses of the cardiovascular system, which are also supported by clinical observations. The new model can be used to gain insight into cardio-arterial interactions across a range of clinical applications.
Chen et al. (Sat,) conducted a other in Cardiovascular function. Coupled left ventricle-systemic artery (LV-SA) model was evaluated on Agreement with published experimental data and prediction of pathological responses. A novel coupled left ventricle-systemic artery model accurately reproduced baseline physiological measurements and predicted varied pathological responses consistent with clinical observations.