Key result
A novel coupled left ventricle-systemic artery model accurately reproduced baseline physiological measurements and predicted varied pathological responses consistent with clinical observations.
Population
Computational coupled left ventricle-systemic artery model incorporating a 3D finite-strain LV and a 1D…
Comparison
Simulation using a combined immersed-boundary… vs Published experimental data and clinical…
Design
Preclinical
Authors
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Hypothesis-generating for ventricular-arterial coupling models; leaves open human validation before any clinical application.
A newly developed coupled left ventricle-systemic artery computational model accurately simulates cardio-arterial interactions in both healthy and pathological scenarios.
Chen et al. (2016) studied Cardiovascular function. Coupled left ventricle-systemic artery (LV-SA) model was evaluated on Agreement with published experimental data and prediction of pathological responses. A novel coupled left ventricle-systemic artery model accurately reproduced baseline physiological measurements and predicted varied pathological responses consistent with clinical observations.
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