Key result
An in-silico modeling strategy coupling a closed-loop cardiovascular system to a HeartMate 3 LVAD was developed to investigate the impact of global cardiovascular conditions on local hemodynamics.
A novel computational modeling strategy coupling global circulation with local 3D hemodynamics allows for detailed investigation of wall shear stress in patients supported by a HeartMate 3 LVAD.
Novel LVAD model links global conditions to local shear stress; leaves open clinical utility pending validation.
This document presents the modeling strategy to address the in-silico study of different LVAD patho-physiological scenarios. The proposed approach employs a closed-loop lumped-parameter compartmental representation of the global circulation in the cardiovascular system (CVS). The CVS is coupled to a HeartMate 3 LVAD, and different cardiovascular conditions are proposed by modification of model parameters. Once the simulation for these conditions are performed, the cardiac function is analyzed in detail, and the global circulation model delivers flow rate waveforms which are employed as boundary conditions in a 3D hemodynamic simulation. This local circulation model is built using a patient-specific geometry of the aortic arch, containing 7 inlet/outlet boundaries, namely: LVAD cannula, aortic root, left and right subclavian arteries, left and right common carotid arteries and thoracic aorta. This model is exploited to investigate the impact of global cardiovascular conditions in the local hemodynamic features, particularly the wall shear stress (WSS) in different spatial regions.
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Blanco et al. (2022) studied LVAD physiology. In-silico blood flow modeling was evaluated on Local hemodynamic features, particularly wall shear stress (WSS). An in-silico modeling strategy coupling a closed-loop cardiovascular system to a HeartMate 3 LVAD was developed to investigate the impact of global cardiovascular conditions on local hemodynamics.
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