What is the clinical evidence from this study?

Study design: Other. Population: Ventricular-arterial coupling. Intervention: Finite Element Modeling. Primary outcome: Simulation of LV pressure-volume loop, aorta pressure-diameter relationship, and pressure waveforms.

What does this research mean for the field?

A novel computational modeling framework coupling high-resolution finite element models of the left ventricle and aorta successfully reproduces physiological ventricular-arterial interactions. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 2, 2018Frontiers in PhysiologyOpen Access

High Spatial Resolution Multi-Organ Finite Element Modeling of Ventricular-Arterial Coupling

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Key result

A novel computational modeling framework coupling high-resolution finite element models of the left ventricle and aorta successfully reproduced physiological ventricular-arterial interactions.

Population

Computational finite element (FE) models of the left ventricle (LV) and aorta

Comparison

Alterations in geometrical or material… vs Baseline simulation

Design

Preclinical

Authors

SSSheikh Mohammad ShavikBangladesh University of Engineering and Technology ZJZhenxiang JiangNanchang Institute of Technology SBSeungik BaekMichigan State University

Discussion

Member takes

Implication

May facilitate in silico studies of ventricular-arterial coupling; leaves open clinical translation pending human validation.

Structured PICO

Population

Computational finite element (FE) models of the left ventricle (LV) and aorta

Intervention

Alterations in geometrical or material parameters of the aorta, and contractility and passive stiffness of the LV

Comparator

Baseline simulation

Outcome

Functional behaviors including LV pressure-volume loop, aorta pressure-diameter relationship, and pressure-waveforms of the aorta, LV, and left atriumsurrogate

A high-resolution finite element modeling framework successfully simulates ventricular-arterial coupling, providing a tool to study interactions between the heart and vasculature.

Limitations

Idealized geometries were used to represent the aorta and LV models, neglecting asymmetrical features and assuming uniform wall thickness.
Homogeneous material properties were assumed despite potential in vivo inhomogeneities.
Dynamical behavior of fluid and its interaction with the vessel wall were neglected.
A rule-based myofiber orientation with linear helix angle variation was used to describe LV microstructure.
Remodeling was simulated by directly manipulating parameters without consideration of growth and remodeling mechanisms.
The model considered only systemic circulation, ignoring the right ventricle and pulmonary circulatory system.

Cite This Study

Shavik et al. (2018) studied Ventricular-arterial coupling. Finite Element Modeling was evaluated on Simulation of LV pressure-volume loop, aorta pressure-diameter relationship, and pressure waveforms. A novel computational modeling framework coupling high-resolution finite element models of the left ventricle and aorta successfully reproduced physiological ventricular-arterial interactions.

synapsesocial.com/papers/6a157a9d37103a43379fcc57 https://doi.org/10.3389/fphys.2018.00119

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High Spatial Resolution Multi-Organ Finite Element Modeling of Ventricular-Arterial Coupling

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

High Spatial Resolution Multi-Organ Finite Element Modeling of Ventricular-Arterial Coupling

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Also Consider