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January 31, 2020Frontiers in PhysiologyOpen Access

Multiscale Modeling Framework of Ventricular-Arterial Bi-directional Interactions in the Cardiopulmonary Circulation

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Why the study?

Ventricular-arterial coupling is key to cardiovascular function, prompting an extension of modeling frameworks to couple patient-specific biventricular and cardiopulmonary arterial models.

Population

One pediatric patient diagnosed with PAH

Comparison

Simulation of increased collagen vs decreased RV contractility vs increased pulmonary arterial resistance

Design

Patient-specific multiscale computational modeling study

Authors

SSSheikh Mohammad ShavikCTChristopher Tossas-BetancourtCFC. Alberto Figueroa

Discussion

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Overview

Advances patient-specific biventricular-pulmonary modeling; leaves open prospective clinical validation.

Structured PICO

P
Population
Patient-specific finite element models reconstructed from magnetic resonance images of a pediatric patient diagnosed with pulmonary arterial hypertension (PAH)
I
Intervention
Computational simulations of progressive PAH characteristics: (1) increased collagen in large pulmonary arteries, (2) decreased right ventricular contractility, and (3) increased total pulmonary arterial resistance
C
Comparator
Baseline calibrated model
O
Outcome
Hemodynamics of the pulmonary vasculature and right ventricular wall stresssurrogate

A patient-specific multiscale computational model of cardiopulmonary circulation demonstrates that distal vasoconstriction impacts right ventricular wall stress and pulmonary hemodynamics more than proximal arterial stiffening in pulmonary arterial hypertension.

Cite This Study

Shavik et al. (2020) studied this question.

synapsesocial.com/papers/6a7d39627786afdcaca00825https://doi.org/10.3389/fphys.2020.00002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation2018 · 25 citations
  2. 2The right ventricle in pulmonary arterial hypertension2014 · 272 citations
  3. 3Mechanisms of Arterial Remodeling in Hypertension2008 · 317 citations
  4. 4Haemodynamic definitions and updated clinical classification of pulmonary hypertension2018 · 3,882 citations
  5. 5High Spatial Resolution Multi-Organ Finite Element Modeling of Ventricular-Arterial Coupling2018 · 29 citations