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SummaryGroups of rats were given a single large dose, or repeated smaller doses of cholestyramine labeled in the carbon skeleton with C14. No radioactivity could be detected in the blood, liver, kidneys or respiratory CO2 of these animals. Significant amounts of radioactivity were found only in feces and in the gastrointestinal tract, indicating that cholestyramine is not absorbed from the gastrointestinal tract of the rat.
Gallo et al. (Fri,) studied this question.