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Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year. Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect. The beneficial effects of hydroxyurea do not become manifest for several months, and its use must be carefully monitored. The long-term safety of hydroxyurea in patients with sickle cell anemia is uncertain.
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Samuel Charache
Michael L. Terrin
Richard D. Moore
New England Journal of Medicine
Johns Hopkins University
Johns Hopkins Medicine
National Heart Lung and Blood Institute
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Charache et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69dbe4205b363cdf1c8362ac — DOI: https://doi.org/10.1056/nejm199505183322001
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