The Y-SK strain of poliomyelitis virus produced more extensive fibroblastic degeneration in monkey and human tissue cultures compared to the immunologically related Lansing strain.
The Y-SK strain of poliomyelitis virus exhibits greater cellular pathogenicity in tissue culture than the immunologically related Lansing strain.
The Y-SK strain of poliomyelitis virus may be titrated in roller tube cultures by observation of the degeneration of monkey testicular fibroblasts within 4 days following the addition of virus to the tissue culture. The extent of fibroblastic degeneration is inversely related to the metabolic activity of the tissue, as measured by the amount of acid production. The 2 immunologically related Y-SK and Lansing strains of poliomyelitis virus differ in the degree to which they cause fibroblastic degeneration, and alter the amount of acid production by the tissue. In contrast to the Lansing strain, the Y-SK strain produces more extensive degeneration in fibroblasts of monkey testicles and also in those of human embryonic skin-muscle.
Ledinko et al. (Mon,) conducted a other in Poliomyelitis virus infection (in vitro). Y-SK strain of poliomyelitis virus vs. Lansing strain of poliomyelitis virus was evaluated on Fibroblastic degeneration and acid production. The Y-SK strain of poliomyelitis virus produced more extensive fibroblastic degeneration in monkey and human tissue cultures compared to the immunologically related Lansing strain.