Key result
The Y-SK strain of poliomyelitis virus produced more extensive fibroblastic degeneration in monkey and human tissue cultures compared to the immunologically related Lansing strain.
Population
Tissue cultures of monkey testicular fibroblasts and human embryonic skin-muscle fibroblasts
Comparison
Y-SK strain of poliomyelitis virus vs Lansing strain of poliomyelitis virus
Design
Preclinical
Follow-up
4 days
Authors
Loading...
Y-SK strain's greater tissue-culture pathogenicity may indicate enhanced virulence; leaves open translation to human disease severity.
The Y-SK strain of poliomyelitis virus exhibits greater cellular pathogenicity in tissue culture than the immunologically related Lansing strain.
Ledinko et al. (1951) studied Poliomyelitis virus infection (in vitro). Y-SK strain of poliomyelitis virus vs. Lansing strain of poliomyelitis virus was evaluated on Fibroblastic degeneration and acid production. The Y-SK strain of poliomyelitis virus produced more extensive fibroblastic degeneration in monkey and human tissue cultures compared to the immunologically related Lansing strain.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: