Key result
Poliomyelitis viruses (Types 1 and 2) successfully propagated in and destroyed monkey testicular fibroblasts in vitro, an effect neutralized by type-specific antibodies.
Population
Monkey testicular tissue fibroblasts in morphologically pure cultures and primary explant cultures
Comparison
Infection with poliomyelitis virus, Types 1 and 2 vs Type specific antibodies
Design
Preclinical
Authors
Loading...
Advances in vitro poliovirus models using monkey fibroblasts; leaves open translation to human vaccines or therapies.
Monkey testicular fibroblasts can support the in vitro growth of poliomyelitis viruses, leading to cell destruction that is preventable by specific antibodies.
Scherer et al. (1952) studied Poliomyelitis virus. Poliomyelitis virus, Types 1 and 2 was evaluated on Viral propagation and cell destruction. Poliomyelitis viruses (Types 1 and 2) successfully propagated in and destroyed monkey testicular fibroblasts in vitro, an effect neutralized by type-specific antibodies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: