Key result
In vitro propagation of poliomyelitis virus in monkey testicular tissue occurred in discrete cycles, yielding up to tenfold greater viral concentrations in the tissue than in the liquid phase.
Population
Monkey testicular tissue cultures infected with poliomyelitis virus, Type 2, Yale-SK strain
Design
Preclinical
Authors
Loading...
May guide in vitro viral studies; leaves open translation to human polio models.
The study characterizes the in vitro growth cycle of poliomyelitis virus in monkey testicular tissue, demonstrating that viral multiplication follows a consistent pattern independent of specific culture techniques.
Scherer et al. (1952) studied Poliomyelitis. In vitro tissue cultivation was evaluated on Viral growth curves and cycles. In vitro propagation of poliomyelitis virus in monkey testicular tissue occurred in discrete cycles, yielding up to tenfold greater viral concentrations in the tissue than in the liquid phase.