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September 1, 1930The Journal of Experimental MedicineOpen Access

Survival and Multiplication of the Virus of Poliomyelitis in Vitro

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Key result

Inoculation of monkeys with remote subplants containing globoid bodies induced experimental poliomyelitis, whereas identical subplants lacking these bodies were avirulent.

Population

7 monkeys successfully inoculated with poliomyelitic virus, and in vitro cultures

Comparison

Inoculation of washed sediments from subplants… vs Inoculation of material from respective tubes of…

Design

Preclinical

Authors

PLPerrin H. LongStatistics AustriaPOPeter K. OlitskyInstitute for Medical ResearchCRC. P. RhoadsGrinnell College

Discussion

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Implication

Links globoid bodies to poliomyelitis pathogenicity in culture; leaves open their role as the human etiologic agent.

Structured PICO

P
Population
In vitro cultivation study using nervous tissues from 7 monkeys successfully inoculated with poliomyelitic virus.
I
Intervention
Inoculation of washed sediments from subplants (7th to 10th transfers) containing 'globoid bodies'
C
Comparator
Inoculation of material from respective tubes of the same transfers free from the minute bodies
O
Outcome
Induction of clinical signs and pathological effects characteristic of experimental poliomyelitis

The study demonstrates that the poliomyelitis virus can multiply in vitro in a modified living tissue-cell culture medium and retain its pathogenicity in monkeys.

Limitations

  • Further elaboration is necessary before concluding that the virus was adsorbed to the globoid bodies.
  • Further elaboration of this study would be necessary before the inference that the virus was adsorbed to the particular bodies could be regarded as a definite hypothesis.

Cite This Study

Long et al. (1930) studied Poliomyelitis (n=7). Inoculation with subplants of poliomyelitis virus cultures vs. Subplants free from minute bodies was evaluated on Pathogenicity (clinical signs and pathological effects of experimental poliomyelitis). Inoculation of monkeys with remote subplants containing globoid bodies induced experimental poliomyelitis, whereas identical subplants lacking these bodies were avirulent.

synapsesocial.com/papers/6a9f8787cd2174b401b20b3chttps://doi.org/10.1084/jem.52.3.361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CONCERNING SURVIVAL AND VIRULENCE OF THE MICROORGANISM CULTIVATED FROM POLIOMYELITIC TISSUES1915 · 11 citations
  2. 2EXPERIMENTS ON THE CULTIVATION OF THE VIRUS OF POLIOMYELITIS1913 · 15 citations
  3. 3Experimental Study of an Antipoliomyelitic Serum from Monkeys Artificially Immunized with an Organism Cultivated from Poliomyelitis Nervous Tissue1933 · 2 citations
  4. 4Propagation of Poliomyelitis Virus in Cultures of Monkey and Human Testicular Tissues.1951 · 34 citations
  5. 5STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES1952 · 167 citations